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Bruckbauer et al

doi: 10.1016/j.biopha.2023.116112 123 ZhangSZhangSWangHChenY

Cognitive Enhancement Studies Cognitive improvement studies in 28-month-old mice (equivalent to elderly humans) using 10 mg/kg body weight administered 5x per week for 3 weeks demonstrated: Significantly faster escape hole finding in Box Maze tests (trials 4 and 5) Evidence of decreased brain inflammation Increased histone deacetylase 2 labeling indicating epigenetic pathway activation Preliminary reversal of age-related cognitive impairment Pain and Anxiety Modulation Anti-pain effects in mice at 0.5 mg/kg showed efficacy comparable to cimetidines human analgesic effects, affecting 7 anti-pain genes (increased) and 2 genes (decreased), with upregulated opioid receptors and related pain-modulating pathways

Furthermore, response surface methods were not employed to explore synergistic or antagonistic interactions of combination formulations, and a bleeding risk due to high-dose Vit E exists

Check specifically for the absence of phylloquinone (K1) and menaquinones (K2)